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1

RNA-Methylation-Dependent RNA Processing Controls the Speed of the Circadian Clock

Fustin, Jean-Michel, Doi, Masao, Yamaguchi, Yoshiaki, Hida, Hayashi, Nishimura, Shinichi, Yoshida, Minoru, Isagawa, Takayuki, Morioka, Masaki Suimye, Kakeya, Hideaki, Manabe, Ichiro, Okamura, Hitoshi

Journal:

Année:

2013

Langue:

english

Fichier:

PDF, 4.49 MB

english, 2013

2

Asymmetric Total Synthesis of Heronamides A-C: Stereochemical Confirmation and Impact of Long-Range Stereochemical Communication on the Biological Activity

Kanoh, Naoki, Itoh, Shunya, Fujita, Kohei, Sakanishi, Kohei, Sugiyama, Ryosuke, Terajima, Yuta, Iwabuchi, Yoshiharu, Nishimura, Shinichi, Kakeya, Hideaki

Journal:

Chemistry - A European Journal

Année:

2016

Langue:

english

Fichier:

PDF, 1.15 MB

english, 2016

3

A chemoproteomics approach to investigate phosphopantetheine transferase activity at the cellular level

Konno, Sho, Ishikawa, Fumihiro, Suzuki, Takehiro, Dohmae, Naoshi, Kakeya, Hideaki, Tanabe, Genzoh

Journal:

Année:

2017

Langue:

english

Fichier:

PDF, 1.78 MB

english, 2017

4

Total synthesis and antimicrobial activity of tumescenamide C and its derivatives

Takahashi, Nobuaki, Kaneko, Kensuke, Kakeya, Hideaki

Journal:

Journal of Organic Chemistry

Année:

2020

Langue:

english

Fichier:

PDF, 303 KB

english, 2020

5

Total Synthesis of (+)-Epoxyquinols A and B

Mitsuru Shoji, Junichiro Yamaguchi, Hideaki Kakeya, Hiroyuki Osada, Yujiro Hayashi

Journal:

Angewandte Chemie

Année:

2002

Langue:

english

Fichier:

PDF, 92 KB

english, 2002

6

Total Synthesis of (+)-Epoxyquinols A and B

Mitsuru Shoji, Junichiro Yamaguchi, Hideaki Kakeya, Hiroyuki Osada, Yujiro Hayashi

Journal:

Angewandte Chemie International Edition

Année:

2002

Langue:

english

Fichier:

PDF, 92 KB

english, 2002

7

Determination by Asymmetric Total Synthesis of the Absolute Configuration of Lucilactaene, a Cell-Cycle Inhibitor in p53-Transfected Cancer Cells

Junichiro Yamaguchi, Hideaki Kakeya, Takao Uno, Mitsuru Shoji, Hiroyuki Osada, Yujiro Hayashi

Journal:

Angewandte Chemie

Année:

2005

Langue:

english

Fichier:

PDF, 338 KB

english, 2005

8

Concise Enantio- and Diastereoselective Total Syntheses of Fumagillol, RK-805, FR65814, Ovalicin, and 5-Demethylovalicin

Junichiro Yamaguchi, Maya Toyoshima, Mitsuru Shoji, Hideaki Kakeya, Hiroyuki Osada, Yujiro Hayashi

Journal:

Angewandte Chemie

Année:

2006

Langue:

english

Fichier:

PDF, 139 KB

english, 2006

9

The Asymmetric Total Synthesis of (+)-Cytotrienin A, an Ansamycin-Type Anticancer Drug

Yujiro Hayashi, Mitsuru Shoji, Hayato Ishikawa, Junichiro Yamaguchi, Tomohiro Tamura, Hiroki Imai, Yosuke Nishigaya, Kenichi Takabe, Hideaki Kakeya, Hiroyuki Osada

Journal:

Angewandte Chemie

Année:

2008

Langue:

english

Fichier:

PDF, 370 KB

english, 2008

10

Determination by Asymmetric Total Synthesis of the Absolute Configuration of Lucilactaene, a Cell-Cycle Inhibitor in p53-Transfected Cancer Cells

Junichiro Yamaguchi, Hideaki Kakeya, Takao Uno, Mitsuru Shoji, Hiroyuki Osada, Yujiro Hayashi

Journal:

Angewandte Chemie International Edition

Année:

2005

Langue:

english

Fichier:

PDF, 338 KB

english, 2005

11

Concise Enantio- and Diastereoselective Total Syntheses of Fumagillol, RK-805, FR65814, Ovalicin, and 5-Demethylovalicin

Junichiro Yamaguchi, Maya Toyoshima, Mitsuru Shoji, Hideaki Kakeya, Hiroyuki Osada, Yujiro Hayashi

Journal:

Angewandte Chemie International Edition

Année:

2006

Langue:

english

Fichier:

PDF, 140 KB

english, 2006

12

The Asymmetric Total Synthesis of (+)-Cytotrienin A, an Ansamycin-Type Anticancer Drug

Yujiro Hayashi, Mitsuru Shoji, Hayato Ishikawa, Junichiro Yamaguchi, Tomohiro Tamura, Hiroki Imai, Yosuke Nishigaya, Kenichi Takabe, Hideaki Kakeya, Hiroyuki Osada

Journal:

Angewandte Chemie International Edition

Année:

2008

Langue:

english

Fichier:

PDF, 370 KB

english, 2008

13

Identification of Cytochrome P450s Required for Fumitremorgin Biosynthesis in Aspergillus fumigatus

Naoki Kato, Hirokazu Suzuki, Hiroshi Takagi, Yukihiro Asami, Hideaki Kakeya, Masakazu Uramoto, Takeo Usui, Shunji Takahashi, Yoshikazu Sugimoto, Hiroyuki Osada

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 428 KB

english, 2009

14

ChemInform Abstract: Factumycin and Its New Derivative RK-1009 Enhance Threonine-phosphorylation of a 60-kDa Protein in Streptomyces griseus.

Hideaki Kakeya, Masayuki Morishita, Ayumi Ikeno, Kimie Kobinata, Tatsuya Yano, Hiroyuki Osada

Journal:

Année:

1999

Fichier:

PDF, 25 KB

1999

15

ChemInform Abstract: Isolation and Biological Activity of a Novel Cytokine Modulator, Cytoxazone.

Hideaki Kakeya, Masayuki Morishita, Kimie Kobinata, Michiyo Osono, Masaaki Ishizuka, Hiroyuki Osada

Journal:

Année:

1999

Fichier:

PDF, 24 KB

1999

16

ChemInform Abstract: Cytoxazone: A Novel Cytokine Modulator Containing a 2-Oxazolidinone Ring Produced by Streptomyces sp.

Hideaki Kakeya, Masayuki Morishita, Hiroyuki Koshino, Tetsu-ichiro Morita, Kimiko Kobayashi, Hiroyuki Osada

Journal:

Année:

1999

Fichier:

PDF, 27 KB

1999

17

ChemInform Abstract: Lucilactaene, a New Cell Cycle Inhibitor in p53-Transfected Cancer Cells, Produced by a Fusarium sp.

Hideaki Kakeya, Shun-ichiro Kageyama, Lin Nie, Rie Onose, Gen Okada, Teruhiko Beppu, Christopher J. Norbury, Hiroyuki Osada

Journal:

Année:

2002

Fichier:

PDF, 26 KB

2002

18

ChemInform Abstract: Epoxyquinol A (I), a Highly Functionalized Pentaketide Dimer with Antiangiogenic Activity Isolated from Fungal Metabolites

Hideaki Kakeya, Rie Onose, Hiroyuki Koshino, Arika Yoshida, Kimiko Kobayashi, Shun-Ichiro Kageyama, Hiroyuki Osada

Journal:

Année:

2002

Fichier:

PDF, 27 KB

2002

19

Azaspirene: A Novel Angiogenesis Inhibitor Containing a 1-Oxa-7-azaspiro[4.4]non-2-ene-4,6-dione Skeleton Produced by the Fungus Neosartorya sp.

Yukihiro Asami, Hideaki Kakeya, Rie Onose, Arika Yoshida, Hiroshi Matsuzaki, Hiroyuki Osada

Journal:

Année:

2003

Fichier:

PDF, 62 KB

2003

20

Epoxyquinol B, a Fungal Metabolite with a Potent Antiangiogenic Activity.

Hideaki Kakeya, Rie Onose, Arika Yoshida, Hiroyuki Koshino, Hiroyuki Osada

Journal:

Année:

2003

Fichier:

PDF, 80 KB

2003

21

A Practical Total Synthesis of Both Enantiomers of Epoxyquinols A (I) and B (II).

Mitsuru Shoji, Satoshi Kishida, Mitsuhiro Takeda, Hideaki Kakeya, Hiroyuki Osada, Yujiro Hayashi

Journal:

Année:

2003

Fichier:

PDF, 80 KB

2003

22

Asymmetric Total Synthesis of Pseurotin A.

Yujiro Hayashi, Mitsuru Shoji, Shinpei Yamaguchi, Takasuke Mukaiyama, Junichiro Yamaguchi, Hideaki Kakeya, Hiroyuki Osada

Journal:

Année:

2003

Fichier:

PDF, 57 KB

2003

23

Novel Non-Peptide Inhibitors Targeting Death Receptor-Mediated Apoptosis.

Hideaki Kakeya, Yasunobu Miyake, Mitsuru Shoji, Satoshi Kishida, Yujiro Hayashi, Takao Kataoka, Hiroyuki Osada

Journal:

Année:

2004

Fichier:

PDF, 182 KB

2004

24

RK-805, an Endothelial-Cell-Growth Inhibitor Produced by Neosartorya sp., and a Docking Model with Methionine Aminopeptidase-2.

Yukihiro Asami, Hideaki Kakeya, Rie Onose, Yie-Hwa Chang, Masakazu Toi, Hiroyuki Osada

Journal:

Année:

2004

Fichier:

PDF, 9 KB

2004

25

Structure—Activity Relationships of Epolactaene Derivatives: Structural Requirements for Inhibition of Hsp60 Chaperone Activity.

Yoko Nagumo, Hideaki Kakeya, Junichiro Yamaguchi, Takao Uno, Mitsuru Shoji, Yujiro Hayashi, Hiroyuki Osada

Journal:

Année:

2004

Langue:

english

Fichier:

PDF, 31 KB

english, 2004

26

Total Synthesis of Epoxyquinols A (I), B (II), and C (III) and Epoxytwinol A (IV) and the Reactivity of a 2H-Pyran Derivative as the Diene Component in the Diels—Alder Reaction.

Mitsuru Shoji, Hiroki Imai, Makoto Mukaida, Ken Sakai, Hideaki Kakeya, Hiroyuki Osada, Yujiro Hayashi

Journal:

Année:

2005

Fichier:

PDF, 18 KB

2005

27

Determination of the Absolute Configuration of Lucilactaene, a Cell-Cycle Inhibitor in p53-Transfected Cancer Cells, by Asymmetric Total Synthesis.

Junichiro Yamaguchi, Hideaki Kakeya, Takao Uno, Mitsuru Shoji, Hiroyuki Osada, Yujiro Hayashi

Journal:

Année:

2005

Fichier:

PDF, 11 KB

2005

28

Epoxytwinol A, a Novel Unique Angiogenesis Inhibitor with C2 Symmetry, Produced by a Fungus

Hideaki Kakeya, Rie Onose, Hiroyuki Koshino, Hiroyuki Osada

Journal:

Année:

2005

Fichier:

PDF, 11 KB

2005

29

First Asymmetric Total Synthesis of Synerazol (I), an Antifungal Antibiotic, and Determination of Its Absolute Stereochemistry.

Yujiro Hayashi, Mitsuru Shoji, Takasuke Mukaiyama, Hiroaki Gotoh, Shinpei Yamaguchi, Munetaka Nakata, Hideaki Kakeya, Hiroyuki Osada

Journal:

Année:

2005

Fichier:

PDF, 11 KB

2005

30

ChemInform Abstract: Total Synthesis and Determination of the Absolute Configuration of FD-838, a Naturally Occurring Azaspirobicyclic Product.

Yujiro Hayashi, Kuppusamy Sankar, Hayato Ishikawa, Yuriko Nozawa, Kazutoshi Mizoue, Hideaki Kakeya

Journal:

Année:

2009

Fichier:

PDF, 19 KB

2009

31

ChemInform Abstract: Novel Natural Products Open the Door of Chemical Biology and Medicinal Chemistry

Hideaki Kakeya, Shinichi Nishimura

Journal:

Année:

2010

Fichier:

PDF, 15 KB

2010

32

Novel mammalian cell cycle inhibitors, spirotryprostatins A and B, produced by Aspergillus fumigatus, which inhibit mammalian cell cycle at G2/M phase

Cheng-Bin Cui, Hideaki Kakeya, Hiroyuki Osada

Journal:

Année:

1996

Langue:

english

Fichier:

PDF, 852 KB

english, 1996

33

Structure–activity relationship of phosmidosine: importance of the 7,8-dihydro-8-oxoadenosine residue for antitumor activity

Mitsuo Sekine, Kazuhisa Okada, Kohji Seio, Hideaki Kakeya, Hiroyuki Osada, Takuma Sasaki

Journal:

Bioorganic & Medicinal Chemistry

Année:

2004

Langue:

english

Fichier:

PDF, 338 KB

english, 2004

34

Synthesis of a biotin-conjugate of phosmidosine O-ethyl ester as a G1 arrest antitumor drug

Mitsuo Sekine, Kazuhisa Okada, Kohji Seio, Tohru Obata, Takuma Sasaki, Hideaki Kakeya, Hiroyuki Osada

Journal:

Bioorganic & Medicinal Chemistry

Année:

2004

Langue:

english

Fichier:

PDF, 341 KB

english, 2004

35

Novel non-peptide inhibitors targeting death receptor-Mediated apoptosis

Hideaki Kakeya, Yasunobu Miyake, Mitsuru Shoji, Satoshi Kishida, Yujiro Hayashi, Takao Kataoka, Hiroyuki Osada

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Langue:

english

Fichier:

PDF, 182 KB

english, 2003

36

Structure–activity relationships of epolactaene derivatives: structural requirements for inhibition of Hsp60 chaperone activity

Yoko Nagumo, Hideaki Kakeya, Junichiro Yamaguchi, Takao Uno, Mitsuru Shoji, Yujiro Hayashi, Hiroyuki Osada

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2004

Langue:

english

Fichier:

PDF, 303 KB

english, 2004

37

Total synthesis and determination of the absolute configuration of FD-838, a naturally occurring azaspirobicyclic product

Yujiro Hayashi, Kuppusamy Sankar, Hayato Ishikawa, Yuriko Nozawa, Kazutoshi Mizoue, Hideaki Kakeya

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2009

Langue:

english

Fichier:

PDF, 319 KB

english, 2009

38

The clinical efficacy of fluoroquinolone and macrolide combination therapy compared with single-agent therapy against community-acquired pneumonia caused by Legionella Pneumophila

Shigeki Nakamura, Katsunori Yanagihara, Koichi Izumikawa, Masafumi Seki, Hiroshi Kakeya, Yoshihiro Yamamoto, Hideaki Senjyu, Atsushi Saito, Shigeru Kohno

Journal:

Journal of Infection

Année:

2009

Langue:

english

Fichier:

PDF, 64 KB

english, 2009

39

Synthesis and cell cycle inhibition of the peptide enamide natural products terpeptin and the aspergillamides

Shun Su, Hideaki Kakeya, Hiroyuki Osada, John A Porco Jr.

Journal:

Année:

2003

Langue:

english

Fichier:

PDF, 855 KB

english, 2003

40

A synthesis of (R)-(-)-mevalonolactone by the combination of enzymatic and chemical methods

Takeshi Sugai, Hideaki Kakeya, Hiromichi Ohta

Journal:

Année:

1990

Langue:

english

Fichier:

PDF, 401 KB

english, 1990

41

A synthesis of (−)-deoxypodocarpic acid methyl ester via an enzymatic enantioselective hydrolysis of the key intermidiate enol ester

Takeshi Sugai, Hideaki Kakeya, Hiromichi Ohta, Mitsuo Morooka, Shigeru Ohba

Journal:

Année:

1989

Langue:

english

Fichier:

PDF, 637 KB

english, 1989

42

Novel mammalian cell cycle inhibitors, cyclotroprostatins A–D, produced by Aspergillus fumigatus, which inhibit mammalian cell cycle at G2/M phase

Cheng-Bin Cui, Hideaki Kakeya, Hiroyuki Osada

Journal:

Année:

1997

Langue:

english

Fichier:

PDF, 999 KB

english, 1997

43

A practical total synthesis of both enantiomers of epoxyquinols A and B

Mitsuru Shoji, Satoshi Kishida, Mitsuhiro Takeda, Hideaki Kakeya, Hiroyuki Osada, Yujiro Hayashi

Journal:

Tetrahedron Letters

Année:

2002

Langue:

english

Fichier:

PDF, 94 KB

english, 2002

44

Reaction modes of oxidative dimerization of epoxycyclohexenols

Mitsuru Shoji, Satoshi Kishida, Yusuke Kodera, Isamu Shiina, Hideaki Kakeya, Hiroyuki Osada, Yujiro Hayashi

Journal:

Tetrahedron Letters

Année:

2003

Langue:

english

Fichier:

PDF, 112 KB

english, 2003

45

Novel triene-ansamycins, cytotrienins A and B, inducing apoptosis on human leukemia HL-60 cells

Hui-ping Zhang, Hideaki Kakeya, Hiroyuki Osada

Journal:

Tetrahedron Letters

Année:

1997

Langue:

english

Fichier:

PDF, 429 KB

english, 1997

46

RK-805, an endothelial-cell-growth inhibitor produced by Neosartorya sp., and a docking model with methionine aminopeptidase-2

Yukihiro Asami, Hideaki Kakeya, Rie Onose, Yie-Hwa Chang, Masakazu Toi, Hiroyuki Osada

Journal:

Année:

2004

Langue:

english

Fichier:

PDF, 279 KB

english, 2004

47

Microbial hydrolysis as a potent method for the preparation of optically active nitriles, amides and carboxylic acids

Hideaki Kakeya, Naoko Sakai, Takeshi Sugai, Hiromichi Ohta

Journal:

Tetrahedron Letters

Année:

1991

Langue:

english

Fichier:

PDF, 245 KB

english, 1991

48

Biosynthesis of 1-aminocyclopropane-1-carboxylic acid moiety on cytotrienin A in Streptomyces sp.

Hui-ping Zhang, Hideaki Kakeya, Hiroyuki Osada

Journal:

Tetrahedron Letters

Année:

1998

Langue:

english

Fichier:

PDF, 129 KB

english, 1998

49

Azaspirene, a fungal product, inhibits angiogenesis by blocking Raf-1 activation

Yukihiro Asami, Hideaki Kakeya, Yusuke Komi, Soichi Kojima, Kiyohiro Nishikawa, Kristin Beebe, Len Neckers, Hiroyuki Osada

Journal:

Année:

2008

Langue:

english

Fichier:

PDF, 381 KB

english, 2008

50

Multiple NF-Y-binding CCAAT boxes are essential for transcriptional regulation of the human C7orf24 gene, a novel tumor-associated gene

Yuji Ohno, Akira Hattori, Masamichi Ueda, Susumu Kageyama, Tatsuhiro Yoshiki, Hideaki Kakeya

Journal:

Année:

2011

Langue:

english

Fichier:

PDF, 834 KB

english, 2011